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1 "Suruchi Mishra"
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Original Article
Seroprevalence of immunoglobulin G antibodies against SARS-CoV-2 in children and adolescents in Delhi, India, from January to October 2021: a repeated cross-sectional analysis
Pragya Sharma, Saurav Basu, Suruchi Mishra, Mongjam Meghachandra Singh
Osong Public Health Res Perspect. 2022;13(3):184-190.   Published online June 10, 2022
DOI: https://doi.org/10.24171/j.phrp.2022.0014
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  • 3 Web of Science
  • 3 Crossref
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Objectives
The aim of this study was to assess changes in the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) immunoglobulin G (IgG) seroprevalence among children and adolescents in Delhi, India from January 2021 to October 2021. Methods: This was a repeated cross-sectional analysis of participants aged 5 to 17 years from 2 SARS-CoV-2 seroprevalence surveys conducted in Delhi, India during January 2021 and September to October 2021. Anti-SARS-CoV-2 IgG antibodies were detected by using the VITROS assay (90% sensitivity, 100% specificity). Results: The seroprevalence among 5- to 17-year-old school-age children and adolescents increased from 52.8% (95% confidence interval [CI], 51.3%−54.3%) in January 2021 to 81.8% (95% CI, 80.9%−82.6%) in September to October 2021. The assay-adjusted seroprevalence was 90.8% (95% CI, 89.8%−91.7%). Seropositivity positively correlated with participants’ age (p<0.001), but not sex (p=0.388). A signal to cut-off ratio ≥4.00, correlating with the presence of neutralization antibodies, was observed in 4,814 (57.9%) participants. Conclusion: The high percentage of seroconversion among children and adolescents indicates the presence of natural infection-induced immunity from past exposure to the SARS-CoV-2 virus. However, the lack of hybrid immunity and the concomitant likelihood of lower levels of neutralization antibodies than in adults due to the absence of vaccination warrants careful monitoring and surveillance of infection risk and disease severity from newer and emergent variants.

Citations

Citations to this article as recorded by  
  • Severe Acute Hepatitis of Unknown Etiology Presenting as Pediatric Acute Liver Failure: Analysis of Likely Etiology, Clinical Course and Outcome
    Bikrant B. Lal, Vikrant Sood, Ekta Gupta, Reshu Agarwal, Rajeev Khanna, Seema Alam
    Journal of Clinical and Experimental Hepatology.2023; 13(5): 912.     CrossRef
  • Anti-SARS-CoV-2 antibody kinetics up to 6 months of follow-up: Result from a nation-wide population-based, age stratified sero-epidemiological prospective cohort study in India
    Puneet Misra, Arvind Kumar Singh, Baijayantimala Mishra, Bijayini Behera, Binod Kumar Patro, Guruprasad R. Medigeshi, Hari Shanker Joshi, Mohammad Ahmad, Pradeep Kumar Chaturvedi, Palanivel Chinnakali, Partha Haldar, Mohan Bairwa, Pradeep Kharya, Rahul Dh
    PLOS ONE.2023; 18(12): e0287807.     CrossRef
  • Seroprevalence of SARS CoV-2 among children after the second surge (June 2021) in a rural district of South India: Findings and lessons from a population-based survey
    Carolin Elizabeth George, Leeberk Raja Inbaraj, Shon Rajukutty, Roshni Florina Joan, Sangeetha Muthuraj, Sindhulina Chandrasingh
    Frontiers in Pediatrics.2022;[Epub]     CrossRef

PHRP : Osong Public Health and Research Perspectives